Dynamic allostery of protein alpha helical coiled-coils
نویسندگان
چکیده
منابع مشابه
Dynamic allostery of protein alpha helical coiled-coils.
Alpha helical coiled-coils appear in many important allosteric proteins such as the dynein molecular motor and bacteria chemotaxis transmembrane receptors. As a mechanism for transmitting the information of ligand binding to a distant site across an allosteric protein, an alternative to conformational change in the mean static structure is an induced change in the pattern of the internal dynami...
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A theory of the helix-coil transition for in-register, two-chain, a-helical, coiled coils such as tropomyosin and paramyosin is developed. The treatment differs from those formulated previously for DNAor collagen-like double helices; in the present treatment, isolated single chains and each of the two strands in the dimer may be partially helical. We calculate the fraction of helix in the two-c...
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We have developed a computational design strategy based on the R-helical coiled-coil to generate modular peptide motifs capable of assembling into metalloporphyrin arrays of varying lengths. The current study highlights the extension of a two-metalloporphyrin array to a four-metalloporphyrin array through the incorporation of a coiled-coil repeat unit. Molecular dynamics simulations demonstrate...
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We report the coiled-coil structure of DNA, which is generated by the dodecanucleotide d(ATATATATATAT). The structure has been determined by single-crystal x-ray crystallography. The molecules form duplexes with single-stranded overhangs, which associate with neighbor molecules and give rise to infinite double helices in a coiled-coil conformation, with staggered nicks in both strands. The coil...
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ژورنال
عنوان ژورنال: Journal of The Royal Society Interface
سال: 2005
ISSN: 1742-5689,1742-5662
DOI: 10.1098/rsif.2005.0068